While battling a Rawhead, Dean gets electrocuted and his heart is damaged. Doctors give him only a few weeks to live. Sam searches for a way to save him and believes he may have found an answer in apreacher who claims to heal the incurable (Kevin McNulty). At the congregation, Dean is chosen, and is cured of his condition. However, he and Sam soon learn that an openly gay teacher died of a heart attack at the same moment that Dean was healed. Further research reveals that deaths occurred in unison with other healings, prompting the brothers to believe that the preacher is using black magic to control a Reaper, healing people in exchange for the lives of those he deems immoral. However, they eventually discover that his wife is behind everything. As the brothers rush to destroy the altar used to control the Reaper, the preacher begins to "heal" a young woman with a brain tumor (Julie Benz), and the Reaper goes after Dean. Sam destroys the altar, and the freed Reaper takes the wife's life, though the young woman is not healed. She later tells Dean that she has made peace with her coming death, and Dean promises to pray for her.
Episode - 13 [Route 666]
Dean is contacted by his first love, Cassie (Megalyn Echikunwoke), who asks him to come to Cape Girardeau in Missouri to investigate a string of racially motivated murders, one of which was her father. Each murder is linked to a mysterious truck that seems to have no driver and leave no tracks. The brothers eventually discover that Cassie's mother, a white woman, left her boyfriend Cyrus for Cassie's African-American father. Cyrus tried to kill him out of anger, but he gained the upper hand with the help of his friends and ended up beating Cyrus to death, dumping Cyrus' body and truck in a nearby swamp. Now Cyrus' spirit has returned and is out for revenge against everyone connected to his death. They eventually put Cyrus to rest by tricking him into driving onto the hallowed ground of an old, burned down church.
Episode - 14 [Nightmare]
Sam has a premonition of a man being killed in Saginaw, Michigan, but the murder is made to look like a suicide. They talk to the victim's son Max (Brendan Fletcher) and fail to find anything supernatural, but warn Max's uncle to be careful. When he, too, dies a mysterious death, Sam and Dean believe the family to be cursed. However, their investigation reveals that Max was regularly beaten by his father and uncle as a child. Sam then has another vision of Max using telekinetic abilities to kill his stepmother, angry at her for not stopping the abuse. The brothers stop Max, and Sam learns from him that, when he was a baby, his mother also died in the same manner as theirs. When Max's anger suddenly resurfaces, he locks Sam in the closet. Sam receives another premonition, showing Max kill Dean. Trying to escape, Sam manages to telekinetically free himself and talk Max out of killing them. A distraught Max then takes his own life.
Episode - 15 [The Benders]
Sam and Dean head to Hibbing, Minnesota, where a young boy witnesses a man disappear. While investigating, Sam is also abducted. Dean pretends to be a police officer in search of his cousin, and teams up with Deputy Kathleen Hudak (Jessica Steen). Although she soon learns Dean's true identity, she allows him to continue investigating with her, as her own brother went missing in the same manner three years before. Despite this, she does not trust him, and handcuffs him to her car when they find the kidnappers' property. Kathleen is soon captured, and learns that the culprits are a human family who hunt and kill people for sport. Dean frees himself and goes after her, but is also captured. However, this distracts the family long enough for Sam and Kathleen to break out from their cages, and the three of them subdue their captors. When Kathleen is later alone with the father, he taunts her about her brother's death, and she shoots him, lying to Sam and Dean that he had tried to escape.
After a construction worker for a new housing development dies in a sinkhole, his brain dissolving within minutes, the brothers head to Oasis Plains, Oklahoma, to investigate. There they learn of mysterious, bug-related deaths in the town. After doing research, they discover that a Native American tribe used to live in the area, but its members were murdered by cavalrymen, with the tribe's chief placing a curse on the land as he died. Sam and Dean determine that the curse will reach its climax that night, and race to warn the family living there as swarms of insects attack. They are able to fight off the bugs and survive through the night, and the insects leave at sunrise.
Episode - 9 [Home]
Sam has nightmares of a family being attacked by a supernatural entity in his and Dean's childhood home, prompting the brothers to return to Lawrence, Kansas, to investigate. They enlist the help of their father's psychic friend, Missouri Mosley (Loretta Devine), to rid the house of a poltergeist. Though Missouri claims to have purified the house, Sam does not believe it was successful, so the brothers watch over the house. When the poltergeist returns, Sam's premonition starts to come true. The brothers rush in to rescue the family, but they themselves are saved by the spirit of their mother, who sacrifices herself to stop the poltergeist.
Episode - 10 [Asylum]
Sam and Dean receive a tip from their father, and travel to Rockford, Illinois, to investigate the haunted Roosevelt Asylum, where criminally insane patients rioted in 1964. One of the riot's victims was the chief psychiatrist (Norman Armour). The spirits there try to communicate rather than attack, leading the brothers to discover that the psychiatrist had been conducting cruel experiments on his patients in order to test his theory that provoking extreme anger would be therapeutic for them. The ghost of the doctor then confronts Sam, causing him to lose his sanity and try to kill his brother. Dean manages to subdue Sam and burn the doctor's corpse, stopping the spirit and returning Sam to normal.
Episode - 11 [Scarecrow]
After their father sends a message telling them to investigate the disappearances of young couples in a rural Indiana town, Sam reveals to Dean that he would rather track down their father, prompting the two to angrily separate. As Sam meets a fellow hitchhiker named Meg Masters (Nicki Aycox), Dean starts the investigation and saves a traveling couple from a living scarecrow. Dean calls Sam about the creature, and discovers that a Vanir is being summoned in the form of a scarecrow to protect the town in exchange for annual sacrifices, with a sacred tree in the town giving it power. Because the couple intended for the ritual escaped, the townspeople choose Dean and Emily (Tania Saulnier)—a girl who lives in town with her aunt and uncle—to be the new sacrifices. However, Sam returns and rescues them, and the scarecrow instead takes Emily's aunt and uncle as its victims. The next morning, Emily and the brothers burn the sacred tree, and then leave town. Meanwhile, Meg hitches a ride on the highway, but slits the driver's throat, collecting his blood into a goblet and using it to communicate with an unknown being.
The brothers are asked by a man whom Dean and his father had previously rescued to investigate the mysterious crash of a commercial airplane that left only seven survivors, with signs pointing to a demonically-possessed passenger causing the accident. When they realize that the demon is now eliminating the survivors one by one, Dean is forced to face his fear of flying by following its next target (Jaime Ray Newman) aboard an airliner. He and Sam manage to get the demon into a restroom on-board, but it flees its host during the exorcism. Despite this, they continue the ritual, sending the demon back to Hell.
Episode - 5 [Bloody Mary]
When a man is killed—his eyeballs having exploded—after his daughter chants "Bloody Mary" three times in front of a mirror, Sam and Dean head to Toledo, Ohio, to investigate. They learn that Bloody Mary(Jovanna Huguet) is the ghost of a young woman who was murdered after her eyes were cut out, and her spirit trapped within the mirror that she died in front of. With the mirror now for sale in an antique store in the town, Bloody Mary has begun to target those nearby who secretly feel guilt over another's death. The brothers must find a way to stop her after a young girl (Marnette Patterson) inadvertently becomes her next target. They track down the original mirror and then smash it, but this only releases Bloody Mary. However, Dean forces her to see her own reflection, and her hatred for those with secrets causes her to vanish.
Episode - 6 [Skin]
After Zach (Aleks Holtz), a college friend of Sam's, is arrested for murdering his girlfriend, the brothers head to St. Louis, Missouri, to investigate. Zach's sister Becky (Amy Grabow) claims that he was with her at the time of the murder, although security footage places him at the scene of the crime. After a similar murder occurs, they realize that the real culprit is a being with shapeshifting abilities. The shape-shifter then captures the two, and plans to use Dean's form to kill Becky. The brothers escape and alert the police. Becky is saved, but the police believe Dean to be her attacker. As Dean later searches through the shapeshifter's lair, Sam visits Becky to make sure that she knows what they are dealing with. However, she reveals herself to be the shapeshifter and knocks Sam unconscious before morphing back into Dean. After the real Dean finds the Becky tied up in the lair, he confronts the shapeshifter and shoots it dead—still in his form.
Episode - 7 [Hookman]
Sam and Dean investigate the brutal death of a college student, and the victim's girlfriend Lori (Jane McGregor) says that the attacker was invisible. More attacks occur, with the victims seemingly connected to the girl. The brothers believe that the killer is the Hook Man, and research indicates that it is the vengeful spirit of Jacob Karns, a preacher who murdered 13 prostitutes in 1862 with the hook that replaced his lost hand and was later put to death for his crimes. To stop the spirit, they must destroy the hook, which unfortunately was reforged into an unknown object by the church after Karns' death. When they search the church for the object, Lori and the brothers are confronted by the Hook Man. Their quick thinking saves them, as the brothers realize that Lori's cross necklace—given to her by her reverend father—is the object, and the spirit vanishes once it is burned.